MEREDITH L. PORTER, CPT, MC, USA, and BETH L. DENNIS, MAJ, MC, USA, Dewitt military Community Hospital, ft Belvoir, Virginia

Am Fam Physician. 2002 Feb 15;65(4):599-607.

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Hyperbilirubinemia is just one of the most common problems encountered in hatchet newborns. Historically, management guidelines were derived from studies on bilirubin toxicity in infants with hemolytic disease. An ext recent referrals support the use of less extensive therapy in healthy term newborns v jaundice. Phototherapy need to be instituted when the full serum bilirubin level is in ~ or above 15 mg every dL (257 mol every L) in infants 25 to 48 hours old, 18 mg every dL (308 mol every L) in babies 49 to 72 hours old, and 20 mg per dL (342 mol every L) in babies older 보다 72 hours. Few term newborns v hyperbilirubinemia have actually serious basic pathology. Jaundice is considered pathologic if the presents within the very first 24 hrs after birth, the total serum bilirubin level rises by more than 5 mg per dL (86 mol every L) every day or is higher than 17 mg per dL (290 mol per L), or an infant has actually signs and also symptoms suggestive of significant illness. The administration goals room to to exclude, pathologic reasons of hyperbilirubinemia and initiate therapy to prevent bilirubin neurotoxicity.


Neonatal hyperbilirubinemia, characterized as a complete serum bilirubin level above 5 mg every dL (86 μmol per L), is a generally encountered problem. Although up to 60 percent of term newborns have actually clinical jaundice in the an initial week of life, couple of have far-reaching underlying disease.1,2 However, hyperbilirubinemia in the newborn duration can be connected with major illnesses such together hemolytic disease, metabolic and also endocrine disorders, anatomic abnormalities that the liver, and also infections.

Jaundice generally results native the deposition of unconjugated bilirubin colors in the skin and also mucus membranes. Depending upon the underlying etiology, this problem may present throughout the neonatal period. Unconjugated hyperbilirubinemia, the primary focus of this article, is the many common kind of jaundice encountered by household physicians. The separate topic the conjugated hyperbilirubinemia is past the limit of this article.

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Infants without figured out risk determinants rarely have total serum bilirubin levels above 12 mg every dL (205 μ mol every L). As the number of risk components increases, the potential to build markedly elevated bilirubin levels additionally increases.2

Common risk factors for hyperbilirubinemia encompass fetal-maternal blood group incompatibility, prematurity, and a previously affected sibling (Table 1).2–4 Cephalohematomas, bruising, and trauma indigenous instrumented shipment may rise the hazard for serum bilirubin elevation. Delay meconium passage also increases the risk. Babies with risk factors should be monitored closely during the very first days to weeks that life.


TABLE 1Risk components for Hyperbilirubinemia in Newborns

Maternal factors Blood type ABO or Rh incompatibility Breastfeeding Drugs: diazepam (Valium), oxytocin (Pitocin) Ethnicity: Asian, aboriginal American Maternal illness: gestational diabetes

Neonatal factors Birth trauma: cephalohematoma, cutaneous bruising, instrumented shipment Drugs: sulfisoxazole acetyl v erythromycin ethylsuccinate (Pediazole), chloramphenicol (Chloromycetin) too much weight ns after bear Infections: TORCH Infrequent feedings Male sex Polycythemia Prematurity previous sibling with hyperbilirubinemia


TABLE 1Risk factors for Hyperbilirubinemia in Newborns

Maternal components Blood form ABO or Rh incompatibility Breastfeeding Drugs: diazepam (Valium), oxytocin (Pitocin) Ethnicity: Asian, aboriginal American Maternal illness: gestational diabetes

Neonatal components Birth trauma: cephalohematoma, cutaneous bruising, instrumented distribution Drugs: sulfisoxazole acetyl through erythromycin ethylsuccinate (Pediazole), chloramphenicol (Chloromycetin) too much weight loss after birth Infections: TORCH Infrequent feedings Male sex Polycythemia Prematurity previous sibling with hyperbilirubinemia